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Ramipril

US Brand Name Altace
Generic Name Ramipril
Other Brand NameCARDACE
Manufacturer AVENTIS, Dr Reddy's
Packing 10
Form Tablet, Capsule
Strength 10 mg, 5 mg, 1.25 mg, 2.5 mg
Available online

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Details

Introduction

Ramipril is a type of medicine from the group of drugs which are ACE inhibitors or angiotensin converting enzyme. This is a pro-drug which converts the active metabolite ramiprilat using liver esterase enzymes. Kidneys mostly excrete these enzymes. It has a half-life of three to 16 hours and it stays longer in liver, kidney and heart failure.

Composition

The composition is on the basis of every tablet milligrams. The Altace tablet which contains ramipril of 1.25 mg, 2.5 mg, 5 mg and 10 mg. There are inactive ingredients which are dihydrate, sodium stearyl fumerate, sulphate, sodium bicarbonate and pregelatinized starch. The tablet with 2.5 mg has FD&C yellow #6 and a yellow iron oxide, the 10 mg tablet has FD&C blue #2 and the 5 mg tablet is containing FD&C yellow #6.

Use

This medicine has indications in treatment of hypertension; congestive heart failure, for susceptible patients over 55 years vulnerable of heart attack, stroke, or need of revascularization procedures, cardiovascular death, diabetic nephropathy with microalbuminuria.

Dosage and administration

Adult has a dose for diabetic nephropathy with initial dosage of 2.5 mg orally once a day for a patient who are not receiving a diuretic medicine. For maintenance dosage of 2.5 to 20 mg per day orally in one to two divided doses. However for adult dose with hypertension has an initial dosage of 2.5 mg orally once a day for a patient not receiving a diuretic and for maintenance dosage is 2.5 to 20 mg per day orally in one to two divided doses. On the other hand, adult dose for congestive heart failure must have a starting dosage of 2.5 mg orally twice a day and a maintenance dosage of 5 mg orally twice a day. Nevertheless, adult dose for left ventricular dysfunction should have an initial dosage of 2.5 mg orally twice a day with its maintenance dosage of 5 mg orally twice a day. While adult dose for myocardial infarction must take an initial dose of 2.5 mg orally twice a day and 5 mg orally twice a day for its maintenance dosage.

Contraindication

This can cause fatal defects to fetus when taken by pregnant women. The person who has a historof allergic reactions, angioedema, undergone dialysis , potassium which is found high level in blood, scleroderma, lupus as well as other related vascular disease.

Important Precautions

In patients who are currently being treated with a diuretic, symptomatic hypotension occasionally can occur following the initial dose of ramipril. To reduce the likelihood of hypotension, the diuretic should, if possible, be discontinued 2 to 3 days prior to beginning therapy with ramipril. Then, if blood pressure is not controlled with ramipril alone, diuretic therapy should be resumed. If the diuretic cannot be discontinued, an initial dose of 1.25 mg ramipril should be used to avoid excess hypotension.

Side effects

Patient must seek fast medical attention right away if any of these side effects occur as his use Ramipril. Severe allergic reactions like rashes, difficulty breathing, swelling of the face, lips, hands, eyes, mouth, throat, hoarseness itching, or tongue, tightness in the chest, dark urine; decreased urination; difficulty swallowing; infections such as fever, persistent chills or sore throat or loss of appetite, irregular heartbeat, pale stools, seizures, stomach pain, nausea or vomiting or even symptoms of low blood pressure.

storage

The proper storage of this ramipril must be 200 C and 250C or 680 F and 770F while it must be away from the reach of your pets or children.