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Lisinopril is an angiotensin-converting enzyme inhibitor that may be prescribed for the treatment of hypertension or acute myocardial infarction. It may also be prescribed as adjunctive therapy in the management of heart failure.

US Brand Name Zestril
Generic Name Lisinopril
Other Brand NameCipril, Listril
Manufacturer ASTRAZENECA, Carsyon, MHRA UK
Packing 7
Form Tablet
Strength 2.5mg, 5mg, 10 mg, 20mg
Available online

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Lisinopril is used in the treatment of hypertension, heart failure, heart attack and diabetic kidney disease.

How it Works

Lisinopril is known as a angiotensin-converting enzyme inhibitor, or ACE inhibitor. Lisinopril works by inhibiting ACE, which means it blocks or inhibits a chemical called angiotensin-converting enzyme, which in turn blocks the production of angiotensin II, angiotensin functions in tightening the blood vessels. Lisinopril thus works to widen the blood vessels and helps to reduce the amount of water put back into your blood by the kidneys.

Common Side effects

Patients who take Lisinopril may suffer from such side effects;

Cold symptoms,
A decline in sexual function,
Vertigo and a drowsy feeling
Decreased blood pressure,
Increased potassium level in blood,
Renal impairment


This is an angiotensin converting enzyme inhibitor drug. The generic name of this drug is lisinopril. Other famous trade names are Cipril and Listril. The drug is manufactured by ASTRAZENRCA, Carsyon, MHRA UK. The medication is a long-acting ACE. It has been used worldwide for the treatment of hypertension and heart related diseases or condition. Lisinopril is the lysine derivative of enalapril. It is also a teratogenic agent. When we say teratogen, meaning it can cause harmful effect does causing birth defects to children.


LISINOPRIL plays the main action for the therapeutic effect of Zestril (lisinopril). Each tablet of lisinopril contains 5.45 mg lisinopril dehydrate. Zestril comes in strengths from 2.5 mg to 40 mg in a form of tablet. It comprises of inactive ingredients like mannitol, magnesium esterate, calcium phosphate, starch, and red and yellow ferric oxide.


Lisinopril is used for adjunct therapy for various disease conditions such as heart failure, renal complication as a result of diabetes mellitus, hypertension, and other disease health condition involving the heart. For treating hypertension, this drug can be use coupled with other hypertensive drugs to achieve its synergistic effect. This is also best used for heart failure especially in the case when the patient is not adequately responding to digitalis and diuretics. It is also used in worst case such as patient who had myocardial infarction. Usage of this drug for MI greatly help the patient survive.

Dosage and administration

For the patient suffering from hypertension but it not on any diuretic treatment a dosage of 10 mg to be given once a day is recommended. It is also important to monitor blood pressure as dosage adjustment greatly depends on the response of the blood pressure to the initial dose of therapy. If ever hypertension does not respond well to this treatment alone, then it can be use synergistically with diuretics. This medication is taken orally with full or empty stomach. While you were on this therapy see to it that you drink plenty amount of water or fluids to cope for excessive sweating and urinating brought about by this therapy.


Zestril is discouraged to use if the patient has hypersensitivity reaction to any component of lisinopril. If you are suffering from disease condition such as swelling of any parts of the face and head, dysphagia or difficulty swallowing, dyspnea or difficulty of breathing. Pregnant women are also discouraged to use this drug. This is not to be use also by children with problems in the kidney. It is necessary to inform your health care provider if you are experiencing such conditions before starting Zestril therapy.

Important Precautions

Consult your medical provider immediately if you are to start with this therapy as some if not the most, medical conditions may react to the treatment of Zestril. Ask for physicianís opinion when you are pregnant or lactating mother. It is important to also inform your doctor when you are taking any dietary supplementation, if you have allergies in any form such as food, medicine, etcetera. Having history of cardiac problems such as aortic stenosis or heart failure, kidney problems, stroke or kidney transplant is also important factor to consider. Please donít keep this to yourself. Tell your doctor right away.

Side effects

Among the listed common side effects of Zestril are headache, easy fatigability, diarrhea, cough, and dizziness. Severe side effects of this drug that prompted medical attention are formation of itchy rash, dyspnea or difficulty of breathing, dysphagia or difficulty swallowing, chest pain, facial swelling, chest tightness, nausea and vomiting, jaundice of the skin and eyes, grogginess, lightheadedness, hematuria characterized by dark colored urine, and irregular beating of the heart.


Keep the medicine in a cool and dry place preferably 15 degree Celsius to 30 degree Celsius. Keep the product away from heat and moisture. Discard properly once expiry date reached.

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