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Proluton Depot, Hydroxyprogesterone Caproate

Proluton Depot Amp. (Hydroxyprogesterone Caproate) is administered to help lower the risk of habitual and threatened abortion.

US Brand Name Proluton Depot
Generic Name Hydroxyprogesterone Caproate
Other Brand Name Proluton Depot
Manufacturer German remedies
Packing 1 ml, 2 ml
Form Amp, Amp
Strength 250 mg, 500 mg

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Hydroxyprogesterone Caproate is a synthetic progestin. It is a clear and sterile solution meant to be injected intramuscularly. It is available under many brand names and is given to women who are at an increased risk of delivering a premature child.


Hydroxyprogesterone Caproate is indicated to reduce the risk of delivering a baby too early from the normal term. It should only be used by women who are pregnant with one baby and have had a preterm baby delivery in the past. This medication is not intended to prevent preterm births in women who are pregnant with more than one baby like twins or triplets. It is also not intended to stop active preterm labor. The mechanism by which it works to reduce the probability of recurrent preterm births is not known.

Dosage and administration

This medication is given as an injection into the gluteal (hip) region by a health care professional, usually once a week. It is advised to start receiving the injections any time between the 16th and 20th week of pregnancy. Continue to receive the injections once a week until the 37th week of pregnancy or when your baby is delivered, whichever happens earlier.

Instructions for administration:

  • Disinfect the vial top with an alcohol swab.
  • Draw 1 ml of the drug into a 3 ml syringe.
  • Change the needle to a 21 gauge, 1 and a half inch needle.
  • Disinfect the skin and inject the drug into the upper outer quadrant of the gluteus maximus muscle. Since the solution is viscous, it is advised to inject the solution slowly for about a minute.
  • Apply pressure on the injection site to minimize bruising.
  • Use this medication as regularly as prescribed to get the maximum benefits.


  • Before taking the medicine, the patient is advised to consult the doctor if she has any allergy to any of the ingredients of the drug. Also, inform the doctor about all the drugs that have already been prescribed.
  • It is important that the patient discusses her medical history with the doctor, especially if there is any history of asthma, blood clotting problems, cancer (especially of the breast, uterus, or other female organs), diabetes, severe headaches, heart problems, high blood pressure, etc.
  • This drug is known to fluctuate the blood sugar levels hence it is advised that a diabetic patient should regularly monitor her sugar levels and in case of any major problems, seek immediate health care.
  • This drug is not indicated in women who have had menopause or in children who are under 16 years of age.
  • Side effects

    The following side effects may occur at the injection site-

  • Pain
  • Swelling
  • Itching
  • Bruising
  • Other than those mentioned above, nausea, vomiting, and diarrhea are also common side effects when using the drug.