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Mirtazapine is an antidepressant that is prescribed to help treat major depressive disorder.

US Brand Name Remeron
Generic Name Mirtazapine
Other Brand NameMirtaz
Manufacturer Sun
Form Tab
Strength 7.5 mg

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Mirtazapine is used for the treatment of major depression and mood disorders. It can be also used as an antiemetic, anxiolytic, hypnotic, and appetite stimulant. This drug is quite a sedative and is suitable for patients with insomnia. It works by restoring the balance of neurotransmitters in the brain.


This drug is used mainly to help manage depression and mood disorders but it can also be given for generalized anxiety disorder, obsessive compulsive disorder, panic disorder, insomnia, post-traumatic stress disorder and migraine prophylaxis. It can be also used as an appetite stimulant for underweight patients.

Dosage and administration

The drug is available in 7.5 mg or 15 mg tablets in the market for patients suffering from depression. It is to be taken orally, preferably once daily at bed time but it can also be taken as two divided doses. An initial oral dose of 7.5 mg at bedtime is suitable for adults with mild to moderate depression. The initial dose of 15 mg daily may be given for those with major depression with a gradual increase in the dose up to 45 mg daily, depending on its clinical response. The changes in dose should be done at intervals of at least 1 to 2 weeks. The disintegrated tablet is also available, which has to stay in the mouth when taken or dissolved in a glass of water before taking it.


The overdose of this drug shows signs and symptoms of,

  • Disorientation,
  • Drowsiness,
  • Impaired memory, and
  • Tachycardia.
  • Taking MAO inhibitors with this drug may cause a serious and possibly fatal drug interaction thus it should be avoided.
  • Alcohol and other CNS depressants taken along with it may cause potentiation of sedative effect.
  • Special precaution should be taken in cases of patients with previos psychiatric disorders, previous suicide attempts, liver disease, renal disease, epilepsy, dyslipidemia, arrhythmia, recent MI and angina, stroke, dehydration, hypotension, and angle closer glaucoma.
  • It should not be taken by the elderly, pregnant women, and breastfeeding mothers.
  • Side effects

    The common side effects of this drug are:

    • Increase in appetite and body weight,
    • Oedema,
    • Drowsiness or sedation,
    • Dizziness,
    • Headache,
    • Jaundice with increased liver enzyme levels,
    • Postural hypotension,
    • Skin rash,
    • Agitation,
    • Tremor,
    • Akathisia,
    • Arthralgia,
    • Myalgia,
    • Restless legs syndrome,
    • Nightmares,
    • Hallucinations,
    • Mania,
    • Paraesthesia,
    • Convulsions may also be evident with higher doses or prolonged therapy.

    It can also cause some serious side effects like myoclonus, reversible agranulocytosis, leucopenia, granulocytopenia, or hyponatremia.