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Escitalopram Oxalate

Escitalopram Oxalate is a selective serotonin reuptake inhibitor prescribed to treat major depression. It may also be prescribed for individuals with generalized anxiety disorder, social anxiety disorder, panic disorder, or obsessive-compulsive disorder.

US Brand Name Lexapro/ Cipralex
Generic Name Escitalopram
Other Brand NameS Citadep, Feliz-S, Escert
Manufacturer Protec, RELIANCE, Torrent, Sava medica
Packing 10
Form Tablet
Strength 5mg, 10mg, 20mg

Available online

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Details

Introduction

Escitalopram Oxalate belongs to the group of Selective Serotonin Reuptake Inhibitors (SSRIs). It is the active form of another drug which is given orally in patients with depression and generalized anxiety disorder. This drug is supposed to work through certain channels and hence restores the balance of serotonin to improve certain mood disorders.

Use

This drug like other SSRIs is prescribed as the first line drug in managing major depressive illness and obsessive compulsive disorder (OCD). Presently, it is also often prescribed to deal with social phobias, eating disorders, and premenstrual psychological disorders. The use of this drug has proven efficacious in generalized anxiety disorders and panic disorders. Some patients complaining of premature ejaculation and kleptomaniac disorder have also benefited from the use of the drug. Cardiologists prefer it for patients of post-myocardial infarction as clinical trials have reported its increased work capacity along with mood elevating properties. Some studies revealed that the use of this drug boosts attitudes and has certain euphoric actions in geriatric patients as well as individuals suffering from other chronic diseases.

Dosage and administration

This drug is available in tablets with the dosage of 5 mg and 10 mg as well as in oral solution, which contains 1 mg/ml base. In acute and maintenance treatment of major depressive disorders, OCD and anxiety disorders, it is prescribed in the dose of 10 to 20 mg once daily. Elderly patients are, however, initiated with half the adult dose. The dosage prescribed for patients with panic disorders and other off-label indications is 5 mg daily and subsequently increased to a maximum of 20 mg daily if necessary.

Warning

  • Proper drug history along with any complaints of previous hypersensitive reactions to any such kind of drugs should be informed before initiating treatment with this drug.
  • The drug has the ability to interfere with cognitive functions and hence such activities should be avoided.
  • It should never be concomitantly administered with Monoamine Oxidase Inhibitors (MAO-I) as it will lead to fatal reactions thus this drug regimen should only begin, at the very least, after 2 weeks of stopping taking MAO-I and vice versa.
  • Pregnant women and lactating mothers should not be given this drug and it should be used cautiously in those with renal and hepatic impairment as well as patients below 18 years old.
  • Side effects

    Like other SSRIs, side effects of this drug are plenty but still it is being widely prescribed due to its efficacy. Discontinuation of the drug may be required when experiencing adverse drug reactions such as insomnia, ejaculatory delay, decreased libido, somnolence, nausea, increased sweating, fatigue and other similar problems.

    Less frequent adverse drug reactions include, postural hypotension, sinusitis, diarrhea, and taste disturbances. Increased appetite, weight gain, and other minor side effects were also associated with chronic use of this drug.

    Suicidal thoughts and suicidal tendencies have also been reported in young adolescent patients when using this drug. The prescribing physician must not be reluctant to decrease the dosage of the drug when such adverse reactions are observed, especially in the young adolescent and elderly patients.