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Amitriptyline Hydrochloride

Amitriptyline Hydrochloride is an antidepressant medication that controls the natural substances in the brain. This drug may help to ease symptoms such as anxiety and tension, while also improving one's mood and facilitating restful sleep.

US Brand Name Elavil
Generic Name Amitriptyline
Other Brand NameSarotena, AMITRIPTYLINE
Manufacturer Merind Limited, Wockhardt, Teva
Packing 10
Form Tablets
Strength 10 mg, 25 mg, 50mg, 75 mg

Available online

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Amitriptyline hydrochloride is used for treating patients with depression in either bipolar disease or other related diseases. There have also been some other additional uses of this drug. Having been derived from the family of drugs that inhibit the uptake of certain neurotransmitters such as norepinephrine and serotonin into the neurons in the brain, the transmitting activity is usually terminated hence it exerts its action.


People suffering from depression are prescribed this drug as an effective therapy for many days. It is primarily useful for patients suffering from endogenous depression. As it helps in restoring the balance of neurotransmitters responsible for depression, there is the need to have proper dosing for the drug. Apart from helping with patients of depression, it can also be used to help manage attention deficit hyperactivity disorder, headaches of different causes, and postherpetic post-viral neuralgia.

Dosage and administration

Like with other psychiatric medications, the dose of Amitriptyline hydrochloride is increased gradually, starting from a low dose such as the 10 mg tablet form for which it is available. Usually a dosage of 50 mg or 75 mg of the drug is given in divided doses throughout the day thus the dosage can then be adjusted according to the patient’s response and side effect profile. Initially, it may take time to produce its action but the benefits can be gradually observed, however, the drowsiness action is often initiated earlier than the anti-depressant action. Sometimes, more than 75 mg is necessary in severe conditions or in hospitalised patients.


  • Since the drug is used in patients with manic depressive or only depressive patients, they may suffer from problems of suicidal tendencies.
  • Prior history of hypertension and pregnant ladies cannot be given this drug.
  • For any kind of abnormal reactions or adverse incidents that are experienced, consult your physician immediately and stop using the drug.
  • Side effects

    Due to its prevention of reuptake of neurotransmitters such as nonepinephrine and serotonin, the side effect profiles are somewhat similar to parasympathetic action.

  • There is dryness of mouth usually observed in most of the patients.
  • Decrease in heart beat.
  • Urinary retention.
  • Vision blurring.
  • Constipation.
  • Sexual dysfunction.
  • Weight changes may be seen as a less serious side effect.
  • More serious side effects will include:

  • Rashes and seizures.
  • Involvement of cardiovascular, neuromuscular, and hypersensitivity reactions.
  • Some patients have gastrointestinal symptoms of liver problems.
  • Nausea and gastric irritation.