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Indapamide Hemihydrate

Indapamide Hemihydrate is prescribed, either alone or together with other agents, for the management of hypertension. It may also be prescribed to treat salt and fluid retention due to congestive heart failure.

US Brand Name Natrilix, Natrilix SR
Generic Name Indapamide Hemihydrate
Manufacturer SERDIA
Packing 10
Form Tablet
Strength 2.5 mg, 1.5 mg
Available online
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Indapamide is used in fluid retention (edema), heart failure, hypertension and kidney stone.

How it Works

Indapamide works by eliminating excess fluids from the body, which then helps to reduce hypertension. Indapamide also works by widening or dilating blood vessels. By widening the blood vessels, Indapamide reduces the pressure inside the blood vessels and over time this leads to a lowering of high blood pressure.

Common Side effects

Patients who take Indapamide may suffer from such side effects;

Tingling sensations,
Blurry vision,
Unusual heartbeat,
Loss of sodium


Indapamide is a diuretic (a drug that increases the flow of urine hence reducing excess body water) which is usually taken through the mouth. It is different from similar drugs in that it has only one sulfonamide group in it. It is a yellowish powder which is slightly acidic and is known to dissolve in alkaline solutions. Indapamide achieves its results by controlling re-absorption of water and salt. The reduction of salt in the muscles of the capillaries, veins and arteries makes them to relax, which is a desired condition for victims of blood pressure and hypertension.


Indapamide is referred to as diuretic medicine. Its ingredients include glycol, cellulose, starch that is from corn and pregelatinezed one, talc, lactose as well as magnesium stearate. This is taken orally with strength of 2.5 mg or 1.5 mg.


There are people who should not use this drug and they include: patients of a kidney disease, people with urination complications, patients of a disease of the liver and hypokalemia patients. It is also important to let your doctor know if you suffer from any of these diseases or gout, lupus, allergic conditions or you are diabetic. These last conditions can not prohibit from taking this drug but they will determine the doctor’s prescription. Being in a place of high temperatures will result in your being thirsty and eventually dehydrate you. This is not desirable when you are under the medication of Indapamide.

Dosage and administration

This drug is usually taken as a single dose everyday in amounts prescribed by the doctor. It is advisable to take this drug as the first thing in the morning with or without taking any food. You should take care not to take this drug in greater doses or for longer periods of time than the doctor's prescription. However, you should always ensure that you complete your dosage even if your feel like you are well. During Indapamide’s medication you should ensure that you attend your clinics as advised. This is important because any harmful effect would be noted at this time.


While taking this drug you should avoid places of high temperatures and demanding exercises. This is because these will result in the increase of your body temperatures as well as dehydration and these two are not desirable.

Important Precautions

You should let the prescribing physician know of any allergy that you could be suffering from and any major diseases that you might have suffered from or do suffer from. This kind information might affect the doctor's prescription. This drug usually makes most people who use it to get dizzy. It is therefore good for you to avoid either driving or using machinery while you are under the medication of Indapamide. This drug gets into a mother's breast milk and it could even harm the suckling baby. It is therefore necessary to discuss with your doctor if you have a breastfeeding child.


Indapamide should not be used together with Cordarone because this could cause a toxicity of lithium.

Side effects

The side effects associated with this drug are dehydration, hypokalemia, hypomagnesemia and dizziness.


Indapamide should be stored at temperatures of between 150C and 300C away from moisture.