Clomiphene belongs to a class of medication called Ovulatory Stimulants. It stimulates an increase in the release of those hormones which are responsible for the development and release of a matured egg (ovulation). It is used to treat the problems of infertility in women. It is a non-steroidal fertility medicine.
Clomiphene is indicated for the treatment of conditions where women wish to become pregnant but face difficulties due to ovulatory dysfunction. It stimulates the ovulation process by increasing the amount of hormones needed to produce an egg.
The conditions associated with the dysfunction include; polycystic ovary syndrome, amenorrhea, galactorrhea, psychogenic amenorrhea, post-oral-contraceptive amenorrhea, and secondary amenorrhea of undetermined etiology.
Dosage and administration
It is available as tablets of strengths 25 mg, 50 mg, and 100 mg. It is advised to strictly follow the doctor’s instructions while taking this medicine. The recommended dose for the patient should begin with a low dose of 50 mg (1 tablet) daily for 5 days. The dose should be increased only in those patients who do not ovulate in response to the 50 mg course of therapy. A low dose is recommended so as to rule out the possibility of Ovarian Hyperstimulation Syndrome.
If ovulation does not occur after the first course of therapy, a second course of 100 mg daily (two 50 mg tablets given as a single daily dose) for 5 days should be given. This course may be started 30 days after the first course. Increasing the dose beyond 100 mg per day for 5 days is not recommended. The majority of patients who will ovulate, do so after the first course of therapy. Intercourse should be timed to coincide with the time of ovulation. If ovulation does not occur after three courses of therapy, further treatment with the medication is not advised and the patient should be reevaluated. If menses does not occur after an ovulatory response, the patient should be reevaluated. Do not take more than the prescribed drug dose. The whole treatment should not extend more than 6 cycles.
Some reported side effects when taking this medication include,