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Progynon Depot Injection

Progynon Depot Injection (Estradiol Valerate) is administered for the treatment of vasomotor symptoms or symptoms of vulvar and vaginal atrophy related to menopause. It may also be prescribed for women who do not produce enough estrogen naturally or for men to manage certain types of prostate cancer.

US Brand Name Progynova Inj.
Generic Name Estradiol Valerate
Other Brand Name Progynon Depot
Packing 10Am.
Form Injection
Strength 10mg/ ml

Available online
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Progynon Depot Injection (Estradiol Valerate) is a long acting estrogen available in the form of an injectable solution. The solution is clear, sterile, colorless to pale yellow. It works by replacing natural estrogen in women who cannot produce enough estrogen. It may also be used in the treatment of advanced prostate cancer by opposing the effects of male hormones.


It is indicated in women to help reduce the symptoms of menopause, such as hot flashes, vaginal dryness, burning and irritation, etc. These symptoms occur in the body when there is decreased production of estrogen. It is also used to treat osteoporosis in women due to reduced estrogen levels. This medication is also indicated in women who are not able to produce enough estrogen, for example, due to hypogonadism or ovarian failure. It may also be used by men in the treatment of advanced prostate cancer.

Dosage and administration

Progynon Depot Injection (Estradiol Valerate) is to be administered intramuscularly. The site of administration is the upper, outer quadrant of the gluteus maximus muscle. Always disinfect the region before injecting the medicine. Inject the medicine slowly to minimize the chance of bruising or swelling. For the treatment of symptoms associated with decreased estrogen levels, the usual dosage is 10 to 20 mg, to be injected every four weeks. The drug is then gradually tapered in 3 to 6 month intervals. It is advised that women should be regularly examined when using this medication to rule out the occurrence of uterine cancer, since this drug increases its risk. For treatment of advanced carcinoma of the prostate, the usual dosage is 30 mg or more, administered every one or two weeks. It is advised that the patient should learn all the necessary instructions before taking the injection at home. It is advised to only take the medication as prescribed by the doctor.


  • Before taking the medicine, the patient is advised to consult the doctor if he or she has any allergy to the drug or other substances. Any medical history like cardiac problems (heart attack, high blood pressure, coronary artery disease), liver disease, blood clotting problems, etc. should be informed too.
  • If the patient has an increased risk of blood clotting problems, then it is advised to consult with the doctor before any surgery or dental procedure because this drug is known to increase the problems of blood clot formation. Do not smoke when on this medication.
  • In case of any unusual vaginal bleeding, report it to your doctor immediately.
  • Use of this drug during pregnancy is contraindicated since it is harmful for the fetus.
  • Side effects

    The following side effects may occur when using this medication;

  • Nausea
  • Vomiting
  • Breast tenderness
  • Weight changes
  • Menstrual changes like vaginal discharge or unusual bleeding
  • Thinning of the scalp hair
  • Headaches
  • Pain in the limbs
  • Abdominal pain
  • Skin rash
  • Customer Reviews
    Rated: 5 / 5 based on 1 customer reviews

    Very good for transexuelle

    Posted by Pierre on 2015-03-05

    1 injection par semaine. Après 9 ou 12 mois, vous avez le maximum de volume de seins que vous pouvez avoir génétiquement. En pilule cela prend 2 à 3 ans. 1 Injection a week. After 9 or 12 months, you have the maximum of volume of breasts which you can have genetically. In pill it sets 2 - 3 years.

    Note: buy-pharma does not imply any medical claims from this review.