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Bromocriptine Mesylate

Bromocriptine Mesylate is a dopamine agonist used to treat symptoms of hyperprolactinemia by reducing the amount of prolactin in the body. It can be used to manage menstrual cycle disorders and premenstrual symptoms, benign tumours in the pituitary gland, Parkinson's disease, etc.

US Brand Name Parlodel
Generic Name Bromocriptine Mesylate
Other Brand NamePROCTINAL
Manufacturer SOLVAY / GSK NOVARTIS
Packing 10
Form Tablet
Strength 1.25 mg, 2.5 mg, 5 mg

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Details

Introduction

Bromocriptine Mesylate is an ergot derivative which acts like a natural substance found in the brain (dopamine). It helps to reduce the levels of certain hormones found in the blood like prolactin and growth hormones. It helps to prevent diseases caused due to the excess of these hormones, however, it is not a cure for them.

Use

Hyperprolactinemia - Bromocriptine Mesylate tablets are indicated for the treatment of conditions associated with hyperprolactinemia, including amenorrhea with or without galactorrhea, decreased sperm production, or infertility. It can be used before an adenectomy (surgical removal of endocrine gland) to reduce the size of tumor before surgery.

Acromegaly - It is indicated in the treatment of acromegaly since it reduces the levels of growth hormone significantly.

Parkinson's Disease - It is also indicated in the treatment of Parkinson’s disease, in conditions where there is the development of tolerance to carbidopa or levodopa and to reduce the side effects (nausea, hallucination, and confusion) associated with extended dosage.

This drug is known to stimulate post synaptic dopamine receptors, which regulate the amount of secretion of prolactin.

Dosage and administration

This drug is available in tablet form in the strengths of 1.25 mg, 2.5 mg, and 5 mg. It is to be taken orally with food.

Hyperprolactinemia and Acromegaly - The initial recommended dose is for the 0.5 to 2.5 mg tablets that are to be taken daily. Additonally, the 2.5 mg tablets may be added to the regimen depending on the patient’s tolerance every 2 to 7 days, until the desired response is achieved.

The daily drug dose should range between 2.5 to 15 mg for hyperprolactinemia and 20 to 30 mg for acromegaly.

Parkinson's Disease - An initial dose of the 0.5 to 2.5 mg tablets, to be taken twice daily. This dose should be gradually increased (2.5 mg every 2 to 4 weeks) until the desired response is achieved. The dose of levodopa should be maintained during this period.

The dose is gradually tapered to reach a maintenance dose at which the desired effect is achieved.

Warning

  • Before taking the medicine, the patient is advised to consult the doctor if he or she has any allergy to ergot medications and inform the doctor of his or her medical history like cardiac problems (heart attack, high blood pressure, coronary artery disease, etc.), liver disease, nervous system (psychosis, schizophrenia, etc.), enzymatic problems (galactose intolerance), etc.
  • This drug causes fluctuations in the blood pressure hence it is advised to monitor the blood pressure regularly.
  • This drug is known to cause drowsy effects in patients hence it is advised not to drive after taking the medicine and avoid alcohol as well.
  • Use this drug during pregnancy only if it is clearly indicated by the doctor.
  • Side effects

    The following side effects may occur with the use of this medication;

  • Nausea
  • Vomiting
  • Constipation
  • Dizziness
  • Drowsiness
  • Tiredness
  • Lightheadedness
  • Headaches