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US Brand Name Nexavar
Generic Name Sorafenib
Other Brand Name Soranib
Manufacturer Cipla
Packing 120
Form Tablet
Strength 200 mg

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Sorafenib is a drug which belongs to the medication class of tyrosine kinase inhibitors. The drug is used to treat certain cancers like renal cancer, liver cancer, or thyroid cancer.


The drug is indicated for the treatment of hepatocellular carcinoma that cannot be treated with surgery, renal cell carcinoma, or thyroid cancer that has spread to other parts of the body and cannot be treated with radioactive iodine anymore. It functions by acting as a kinase inhibitor. Kinase molecules are thought to be involved in cell signaling, angiogenesis, and apoptosis.

Dosage and administration

Sorafenib is available as tablets of 200 mg concentration. The route of administration is oral. The recommended daily dose of the drug in an adult is 400 mg, two divided doses of 200 mg each that are to be taken as prescribed by the doctor. The drug should be taken with a full glass of water and the tablet should not be chewed or broken. The drug should be taken on an empty stomach, one or two hours before a meal. The accurate drug dose depends on your body weight, age, sex, and your response to the drug. Always follow the doctor’s instructions while taking this medicine. In case you miss a normal dose of the drug, do not take two doses to compensate for the missed dose. Just continue with the usual drug regime on your next dose. Your doctor would advise you on the proper use of this medication.


  • Tell your doctor if you are allergic to this drug or to any other substances.
  • Tell your doctor if you have any personal or family history of lung cancer, kidney problems, liver disorders, cardiac disorders like irregular heart beat, angina, or QT prolongation in your ECG, as well as the full list of medication or supplements that you are taking.
  • Hand, foot and mouth disease, skin rashes, Stevens-Johnson syndrome and toxic epidermal necrolysis are some of the severe side effects of this drug. Any symptoms of these must be immediately dealt with by discontinuing the use of the drug and seeking medical care.
  • Do not stop taking the drug without consulting your doctor.
  • The drug is known to cause teratogenic effects on the fetus hence it is not advised to get pregnant if you are on this drug regime.
  • Avoid going for any vaccination or immunization if you are on this drug regime. Furthermore, it is advised not to get wounded by any cuts or bruises since this drug affects your body's wound healing capacity.
  • The drug is known to cause hypertension hence the blood pressure of patients on this drug regime must be closely monitored.
  • Side effects

  • Nausea
  • Diarrhea
  • Loss of appetite
  • Weight loss
  • Dry mouth
  • Acne
  • Hair loss or thinning of hair
  • Skin rash
  • Itchiness
  • Constipation
  • Pain in the abdomen